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- W2382028515 abstract "[Objective] To study the effection of influenza A(H1N1)virus vaccine on expression of CD4+CD25+ Foxp3 of mice.[Methods] Total 72 Balb/c mice of experimental SPF were used and divided randomly into high(0.3 mL),middle(0.2 mL) and low(0.1 mL)dose and control groups according to vaccine dose.These mice were immuned by influenza A(H1N1) inactivated vaccine and terminated at 4、8、12、19、26、34 day following vaccine.The CD4+,CD25+,Foxp3 expression of spleen cells were analyzed with FACS.[Results] The doses of injected vaccine effected on expressions of the three proteins.The Foxp3 and CD4+CD25+ average values in group 0.1 mL were significantly lower but higher in group 0.3 mL than those of control group(P0.01);the CD4+CD25+Foxp3 average value in group 0.1 mL was significantly higher than that of control group(P0.01).The average values of the three proteins were different in different time points.There were no difference in Foxp3,but the average values of CD4+CD25+ in 34th day was lower than that in 4th day significantly(P0.05),the average values of CD4+CD25+ Foxp3 in 19th and 26th day were higher than that of the 4th day significantly(P0.05).[Conclusion] Influenza A(H1N1) virus vaccine could increase CD4+CD25+ Foxp3 T cell immune function." @default.
- W2382028515 created "2016-06-24" @default.
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- W2382028515 date "2012-01-01" @default.
- W2382028515 modified "2023-09-26" @default.
- W2382028515 title "Effection of influenza A(H1N1) virus vaccine on expression of CD4~+CD25~+ Foxp3 in mice" @default.
- W2382028515 hasPublicationYear "2012" @default.
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