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- W2382033675 abstract "Objective:To explore the reasonable use of warfarin for anticoagulation in patients with chronic at rial fibrillation(CAF). Method:Total 234 CAf patients at high risk of stroke received anticoagulation with warfarin. The changes of time of reaching the target international normalised ratio (INR), the INR value, the maintain dosage of warfarin and the average annual rates for bleeding events and embolic events affected by such factors as different initial dosage of warfarin, different intensity of anticoagulation and fenility (age ≥65 ) were observed. Result:Compared with the small initial dosaged. 25 mg/d) of warfarin group, the common initial dosage(2. 5 mg/ d) of warfarin group reached the target INR and the stable INR with shorter time ( P 0. 01, respectively) and tended to decrease the rate of embolic, but the INR value, the maintain dosage of warfarin and the bleeding rate showed no difference. Compared with the low intensity of anticoagulation group, the middle intensity of anticoagulation group could significantly decrease the rate of embolic(P 0. 05). Although it increased the rate of bleeding ( P 0. 05), there were no serious bleeding events; The elderly (agejs65) didn't show higher bleeding rate but need less maintain dosage of warfarin ( P 0. 01) to keep the target INR. Conclusion: It's better to anticoagulate with common initial dosage of warfarin in patients with CAf. patients with CAf at high risk of stroke should be given middle intensity of anticoagulation. Anticoagulating with warfarin didn't increase the bleeding risk in the elderly (agej65)." @default.
- W2382033675 created "2016-06-24" @default.
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- W2382033675 date "2006-01-01" @default.
- W2382033675 modified "2023-09-23" @default.
- W2382033675 title "Clinical study of anticoagulation with warfarin in patients with chronic atrial fibrillation" @default.
- W2382033675 hasPublicationYear "2006" @default.
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