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- W2382039897 abstract "Objective: To study the effects of Hyssopus officinalis L. on intracellular expression of Th1 /Th2 cytokines. Methods: BALB/c female mice were randomly divided into normal group,control group,dexamethasone group,high-dosage treatment group and low-dosage treatment group of Hyssopus officinalis L. Except normal group,the other four groups were sensitized intraperitoneally and stimulated by aerosolizing ovalbumin (OVA) to establish an asthmatic model. Hyssopus officinalis L.,according to the corresponding dose was administered intragastrically after the first sensitization. Twenty-four hours after the last stimulation,bronchoalveolar lavage fluid (BALF) was collected. The levels of cytokines interleukin-4(IL-4)and interferon-γ(IFN-γ) in bronchoalveolar lavage fluids (BALF) were determined by Enzyme Linked Immunosorbent Assay(ELISA) and the eosinophils(EOS) was counted by light microscope. Results: Compared with model group,the level of IL-4 and eosinophils(EOS) count in BALF reduced markedly in Hyssopus officinalis L. group(P0.01). The level of IFN-γ in Hyssopus officinalis L group was higher than that in model group (P0.01). There was no significant difference between dexamethasone group and high-dosage treatment group of Hyssopus officinalis L. Conclusion: The Uigur herbal medicine Hyssopus officinalis L is quite effective in treating asthma by inhibiting production of IL-4,regulating the balance of Th1 and Th2 cytokines and restraining the assemble of inflammatory cells to treat allergic asthma." @default.
- W2382039897 created "2016-06-24" @default.
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- W2382039897 date "2008-01-01" @default.
- W2382039897 modified "2023-09-23" @default.
- W2382039897 title "Effects of Uigur Herb Hyssopus officinalis L. on Cytokines in Allergic Asthma Mice" @default.
- W2382039897 hasPublicationYear "2008" @default.
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