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- W2382073123 abstract "Objective In order to explore the serum FGF19level and its relationship with serum leptin(LP)in individuals with different levels of glucose tolerance. Methods Ninety individuals of NGT,IGT and T2DM(n=30,each)were involved.Serum FGF19and LP levels were measured by ELISA. The relationship between FGF19 and LP or other relative metabolic parameters were evaluated. Results Compared with NGT group,serum FGF19levels in IGT and T2DM groups were decreased[(391.84± 63.46)vs(312.89±62.57)ng/L,(391.84±63.46)vs(256.12±61.66)ng/L,P0.01],serum LP levels were increased[(6.13±1.12)vs(6.82±0.90)μg/L,(6.13±1.12)vs(8.31±1.35)μg/L,P0.01].LP, WC and HOMA-IR were the independent predictors of FGF19 levels in T2DM group. Conclusion Decreased level of FGF19 may contribute to the occurrence and development of T2DM. Decreased level of FGF19is closely related to LP-resistance and HOMA-IR.FGF19might be a treatment target in T2DM and obesity control." @default.
- W2382073123 created "2016-06-24" @default.
- W2382073123 creator A5076803428 @default.
- W2382073123 date "2014-01-01" @default.
- W2382073123 modified "2023-09-26" @default.
- W2382073123 title "Observation of change of serum FGF19levels and its relationship with leptin in individuals with different levels of glucose tolerance" @default.
- W2382073123 hasPublicationYear "2014" @default.
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