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- W2382079461 abstract "AIM To construct recombinant SEA gene eukaryotic expression vectors and observe its immunological effects in vivo against murine hepatoma. Methods Gene recombination techniques were used to construct eukaryotic expression vectors containing SEA genes. After in vivo transfection of pLXSN-SEA mediated by liposome mediation, therapeutic effects of pLXSN-SEA were observed. Results pLXSN-SEA had been constructed successfully. After in vivo transfection of pLXSN-SEA, the tumor size volume in mice bearing hepatoma mould reduce obviously, of them, tumors of 4 in 10 mice disappeared completely and survival period of the mice also lengthened. Cytotoxic assay showed that the SEA expression could induce activation of mouse splenic lymphocytes and made tumor cells easily killed. Conclusion SAg SEA possesses strong anti-tumor activity. It is a hopeful candidate for biological therapy of tumors." @default.
- W2382079461 created "2016-06-24" @default.
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- W2382079461 date "2002-01-01" @default.
- W2382079461 modified "2023-09-23" @default.
- W2382079461 title "Construction of recombinant SEA gene eukaryotic expression vectors and its induction of immune response against murine hepatoma" @default.
- W2382079461 hasPublicationYear "2002" @default.
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