Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382088433> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W2382088433 abstract "The study aimed to investigate the cytotoxic effects of mouse anti-human DR5 monoclonal antibody(mDRA-6) on leukemic cell U937 and the underlying mechanism.Cytotoxicity exerted by mDRA-6 on U937 was measured by MTT colorimetry and the apoptosis of U937 after insulting by mDRA-6(10 mg/L) for 4 h was analyzed by FCM with Annexin V-FITC/PI staining.The expressions of caspase 8,10,3,9 in U937 cells were detected by Western blotting after treatment with mDRA-6.Furthermore,the inhibitors for caspase 8,10,3 were used to block the alternatively apoptotic pathways.FCM detection indicated that the apoptosis rate of the U937 cells was 69.03% in the presence of 10 mg/L mDRA-6 for 4 h.The active cleavage products of caspase 10,3,9 and Cytochome C in U937 cells were detected by Western blotting after treatment with mDRA-6 in time dependent manner,but caspase 8 was not.Caspase 10,3 inhibitors partly inhibited the apoptosis of U937 cells induced by mDRA-6,while caspase 8 inhibitor did not.The results mean that mDRA-6 is an agonistic anti-human DR5 monoclonal antibody which can induces U937 cells apoptosis through death-receptor and mitochondrial signal transduction pathways,respectively." @default.
- W2382088433 created "2016-06-24" @default.
- W2382088433 creator A5055543806 @default.
- W2382088433 date "2010-01-01" @default.
- W2382088433 modified "2023-09-25" @default.
- W2382088433 title "The mechanism of U937 cell apoptosis induced by a novel agonistic anti-human DR5 monoclonal antibody" @default.
- W2382088433 hasPublicationYear "2010" @default.
- W2382088433 type Work @default.
- W2382088433 sameAs 2382088433 @default.
- W2382088433 citedByCount "0" @default.
- W2382088433 crossrefType "journal-article" @default.
- W2382088433 hasAuthorship W2382088433A5055543806 @default.
- W2382088433 hasConcept C108634530 @default.
- W2382088433 hasConcept C153911025 @default.
- W2382088433 hasConcept C185592680 @default.
- W2382088433 hasConcept C190283241 @default.
- W2382088433 hasConcept C55493867 @default.
- W2382088433 hasConcept C86803240 @default.
- W2382088433 hasConcept C95444343 @default.
- W2382088433 hasConceptScore W2382088433C108634530 @default.
- W2382088433 hasConceptScore W2382088433C153911025 @default.
- W2382088433 hasConceptScore W2382088433C185592680 @default.
- W2382088433 hasConceptScore W2382088433C190283241 @default.
- W2382088433 hasConceptScore W2382088433C55493867 @default.
- W2382088433 hasConceptScore W2382088433C86803240 @default.
- W2382088433 hasConceptScore W2382088433C95444343 @default.
- W2382088433 hasLocation W23820884331 @default.
- W2382088433 hasOpenAccess W2382088433 @default.
- W2382088433 hasPrimaryLocation W23820884331 @default.
- W2382088433 hasRelatedWork W2348524677 @default.
- W2382088433 hasRelatedWork W2349684682 @default.
- W2382088433 hasRelatedWork W2350028519 @default.
- W2382088433 hasRelatedWork W2355707334 @default.
- W2382088433 hasRelatedWork W2361394353 @default.
- W2382088433 hasRelatedWork W2365162598 @default.
- W2382088433 hasRelatedWork W2366435934 @default.
- W2382088433 hasRelatedWork W2367491297 @default.
- W2382088433 hasRelatedWork W2368523882 @default.
- W2382088433 hasRelatedWork W2368931918 @default.
- W2382088433 hasRelatedWork W2371223615 @default.
- W2382088433 hasRelatedWork W2373118421 @default.
- W2382088433 hasRelatedWork W2374137370 @default.
- W2382088433 hasRelatedWork W2374859761 @default.
- W2382088433 hasRelatedWork W2375093605 @default.
- W2382088433 hasRelatedWork W2376524233 @default.
- W2382088433 hasRelatedWork W2382325980 @default.
- W2382088433 hasRelatedWork W2383666797 @default.
- W2382088433 hasRelatedWork W2383877864 @default.
- W2382088433 hasRelatedWork W2387540303 @default.
- W2382088433 isParatext "false" @default.
- W2382088433 isRetracted "false" @default.
- W2382088433 magId "2382088433" @default.
- W2382088433 workType "article" @default.