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- W2382096599 abstract "Objective To study the anti-HIV-1 activity and toxicity of the potentilla anserine L.extract.Methods TZM-bl and MT-4 cell lines were infected with HIV-1 laboratory-adapted strain(SF33),two HIV-1 clinical isolates(XJDC257,020100968)and four HIV-1 pseudotype viruses(9-14,18-36,74-2 and Z20-11).The activity of inhibiting replication of HIV-1 was observed respectively by using Luciferase assay system based on TZM-bl cell line and P24 antigen expression detection based on MT-4 cell line..The TZM-bl,MT-4 and PBMCs were co-cultured with potentilla anserine L.extract of different concentrations,then CCK-8 kit was used to detect the number of the living cells for evaluating the cytotoxicity of the extract.Results The IC50 and SI of the potentill anserine L.extract against SF33 was 6.2 μg/mL,26.4 by using MT-4 cell line and 4.7 μg/mL,73.5 by using TZM-bl cell line.The IC50 and TI of the extract against HIV-1 clinical isolates XJDC257 and 020100968 was 2.1 μg/mL,70.6 and 1.9 μg/mL,77.6,respectively.The IC50 of the extract against the HIV-1 pseudotype viruses 9-14,18-36,74-2 and Z20-11 was 1.8 μg/mL,1.0 μg/mL,3.4 μg/mL and 3.5 μg/mL,respectively and therapeutic index(TI) was 81.9,147.5,43.4 and 42.1,respectively.Conclusion:The potentilla anserine L.extract could inhibit the replication of HIV-1 in vitro." @default.
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- W2382096599 date "2012-01-01" @default.
- W2382096599 modified "2023-09-23" @default.
- W2382096599 title "Study on the anti-HIV-1 activity and toxicity of the potentilla anserine L. extract" @default.
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