Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382100040> ?p ?o ?g. }
- W2382100040 endingPage "977" @default.
- W2382100040 startingPage "969" @default.
- W2382100040 abstract "The power of a single engineered organism is limited by its capacity for genetic modification. To circumvent the constraints of any singular microbe, a new frontier in synthetic biology is emerging: synthetic ecology, or the engineering of microbial consortia. Here we develop communication systems for such consortia in an effort to allow for complex social behavior across different members of a community. We posit that such communities will outpace monocultures in their ability to perform complicated tasks if communication among and between members of the community is well regulated. Quorum sensing was identified as the most promising candidate for precise control of engineered microbial ecosystems, due to its large diversity and established utility in synthetic biology. Through promoter and protein modification, we engineered two quorum sensing systems (rpa and tra) to add to the extensively used lux and las systems. By testing the cross-talk between all systems, we thoroughly characterized many new inducible systems for versatile control of engineered communities. Furthermore, we've identified several system pairs that exhibit useful types of orthogonality. Most notably, the tra and rpa systems were shown to have neither signal crosstalk nor promoter crosstalk for each other, making them completely orthogonal in operation. Overall, by characterizing the interactions between all four systems and their components, these circuits should lend themselves to higher-level genetic circuitry for use in microbial consortia." @default.
- W2382100040 created "2016-06-24" @default.
- W2382100040 creator A5028013622 @default.
- W2382100040 creator A5052945096 @default.
- W2382100040 date "2016-05-19" @default.
- W2382100040 modified "2023-10-12" @default.
- W2382100040 title "Quorum Sensing Communication Modules for Microbial Consortia" @default.
- W2382100040 cites W1502461125 @default.
- W2382100040 cites W1566270180 @default.
- W2382100040 cites W1587550513 @default.
- W2382100040 cites W1588164239 @default.
- W2382100040 cites W1592400292 @default.
- W2382100040 cites W1904615796 @default.
- W2382100040 cites W1935018540 @default.
- W2382100040 cites W1956082477 @default.
- W2382100040 cites W1970422609 @default.
- W2382100040 cites W1970650417 @default.
- W2382100040 cites W1972352642 @default.
- W2382100040 cites W1974028960 @default.
- W2382100040 cites W1977624796 @default.
- W2382100040 cites W1977782410 @default.
- W2382100040 cites W1979187741 @default.
- W2382100040 cites W1982394109 @default.
- W2382100040 cites W1994532782 @default.
- W2382100040 cites W1996205067 @default.
- W2382100040 cites W2001426985 @default.
- W2382100040 cites W2002783575 @default.
- W2382100040 cites W2017021191 @default.
- W2382100040 cites W2020907152 @default.
- W2382100040 cites W2021099440 @default.
- W2382100040 cites W2026197731 @default.
- W2382100040 cites W2028279248 @default.
- W2382100040 cites W2028974656 @default.
- W2382100040 cites W2029139718 @default.
- W2382100040 cites W2029150230 @default.
- W2382100040 cites W2029945156 @default.
- W2382100040 cites W2031284066 @default.
- W2382100040 cites W2032414816 @default.
- W2382100040 cites W2035448929 @default.
- W2382100040 cites W2046706423 @default.
- W2382100040 cites W2048226096 @default.
- W2382100040 cites W2061433174 @default.
- W2382100040 cites W2070876566 @default.
- W2382100040 cites W2079536459 @default.
- W2382100040 cites W2083878238 @default.
- W2382100040 cites W2086437396 @default.
- W2382100040 cites W2092462789 @default.
- W2382100040 cites W2093514941 @default.
- W2382100040 cites W2098626852 @default.
- W2382100040 cites W2099082448 @default.
- W2382100040 cites W2100636437 @default.
- W2382100040 cites W2102473891 @default.
- W2382100040 cites W2103581925 @default.
- W2382100040 cites W2109842871 @default.
- W2382100040 cites W2111870329 @default.
- W2382100040 cites W2114228460 @default.
- W2382100040 cites W2117280310 @default.
- W2382100040 cites W2118464978 @default.
- W2382100040 cites W2118521369 @default.
- W2382100040 cites W2120575468 @default.
- W2382100040 cites W2123992133 @default.
- W2382100040 cites W2126922170 @default.
- W2382100040 cites W2131869707 @default.
- W2382100040 cites W2135986228 @default.
- W2382100040 cites W2140181134 @default.
- W2382100040 cites W2143197862 @default.
- W2382100040 cites W2143337671 @default.
- W2382100040 cites W2145352273 @default.
- W2382100040 cites W2147516046 @default.
- W2382100040 cites W2149202606 @default.
- W2382100040 cites W2150389885 @default.
- W2382100040 cites W2150967287 @default.
- W2382100040 cites W2161466984 @default.
- W2382100040 cites W2163543246 @default.
- W2382100040 cites W2164957727 @default.
- W2382100040 cites W2169010693 @default.
- W2382100040 cites W2325907107 @default.
- W2382100040 cites W2338504761 @default.
- W2382100040 cites W4230734908 @default.
- W2382100040 doi "https://doi.org/10.1021/acssynbio.5b00286" @default.
- W2382100040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5603278" @default.
- W2382100040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27172092" @default.
- W2382100040 hasPublicationYear "2016" @default.
- W2382100040 type Work @default.
- W2382100040 sameAs 2382100040 @default.
- W2382100040 citedByCount "148" @default.
- W2382100040 countsByYear W23821000402016 @default.
- W2382100040 countsByYear W23821000402017 @default.
- W2382100040 countsByYear W23821000402018 @default.
- W2382100040 countsByYear W23821000402019 @default.
- W2382100040 countsByYear W23821000402020 @default.
- W2382100040 countsByYear W23821000402021 @default.
- W2382100040 countsByYear W23821000402022 @default.
- W2382100040 countsByYear W23821000402023 @default.
- W2382100040 crossrefType "journal-article" @default.
- W2382100040 hasAuthorship W2382100040A5028013622 @default.
- W2382100040 hasAuthorship W2382100040A5052945096 @default.
- W2382100040 hasBestOaLocation W23821000402 @default.