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- W2382106527 abstract "Objective:To observe the morphology of dopaminergic neurons in the substantia nigra pars compacta (SNc) and c-fos expression in the caudate-putamen of 6-hydroxydopamine (6-OHDA) lesioned rats, and to explore the correlation between c-fos expression and lesion size.Methods: Rats received a unilateral injection of 6-OHDA into SNc. The abnormal rotations induced by apomorphine (APO) were investigated at 1 d,7 d, 14 d and 21 d after lesion. Meanwhile, changes of the morphology of dopaminergic neurons and c-fos expression were observed with HE and Nissl body staining, electron microscopic and immunocytochemistry methods. Results: The number of dopaminergic neurons decreased gradually in the lesioned site and its ultrastructure damage was more severe. Eighty percent of dopaminergic neurons were lost. c-fos was up-regulated in the ipsilateral striatum and contralateral rotations surpassed 7 r/min. Conclusion:Dopaminergic neurons loss is the foundation of behavioral changes and up-regulation of c-fos in the ipsilateral caudate-putamen.Intrinsic relations may exist between them." @default.
- W2382106527 created "2016-06-24" @default.
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- W2382106527 date "2005-01-01" @default.
- W2382106527 modified "2023-09-25" @default.
- W2382106527 title "Changes of dopaminergic neuron morphology and expression of c-fos in corpusstriatum after rat substantia nigra lesion" @default.
- W2382106527 hasPublicationYear "2005" @default.
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