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- W2382107856 abstract "Objective To investigate the protein levels of PTEN and p-tau(Ser396) in the process of cellular models of Alzheimer's disease in SH-SY5Y cell and primary cortical neuronal cells induced by Aβ25-35.Methods SH-SY5Y cell and primary cortical neuronal cells were treated with 40 μmol/L and 20 μmol/L Aβ25-35 respectively.MTT assay was applied to detect the cell viability,and cell morphology and the level of p-tau(Ser396) protein were used to determine the establishment and identification of cellular models of Alzheimer's disease.In the mean time,we observed the changes of PTEN protein and discussed the relevance with AD.Results The studies show that cell viability decreased,cell shrinkage,cell neuritis disruption and hyperphosphorylation of tau protein were found in the two cellular models.After exposed to Aβ25-35,the level of hyperphosphorylation of tau protein increased at 6 h and reached the peak at 12~24 h,the level of PTEN protein increased at 3h and reached the peak at 6~12 h,then it declined.Furthermore,the increase of levels of PTEN protein precedes the increase of level of phosphorylation tau protein.Conclusion PTEN may have certain relevance with the process of cellular models of Alzheimer's disease induced by Aβ25-35;the expression of PTEN may increase in the early development." @default.
- W2382107856 created "2016-06-24" @default.
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- W2382107856 date "2012-01-01" @default.
- W2382107856 modified "2023-09-23" @default.
- W2382107856 title "The Changes of PTEN and p-tau Protein Level in the Process of Cellular Models of Alzheimer's Disease Induced by Aβ_(25-35)" @default.
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