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- W2382108889 abstract "Objective Silk fibroin(SF)as drug carrier and metformin as a model drug,to prepare metformin silk fibroin microspheres,and optimize the optimal conditions of preparation technology.Methods Liquid paraffin as oil phase,regenerated silk fibroin solution as water phase,Span 80 as oil soluble emulsifier,metformin SF microspheres were prepared by emulsion solidification method,the particle diameter and its distribution were measured by Laser particle sizer,the factors that affected drug loading and entrapment efficiency were investigated by single factor test,then the optimal preparation technology was optimized by orthogonal test.Results The microspheres were spherical in shape,and microsphere diameters were on the order of 4~40 μm.The factors that greatly affected the drug loading and entrapment efficiency were the mass ratio(metformin/SF),water/oil phase ratio and rotation speed.The optimal preparation technology was obtained:the rotation speed was 300 rpm,the mass ratio was 7 %,water/oil phase ratio was 11:100,the drug loading up to 5.8%.Conclusion This method of preparing metformin SF microsphere was simple,no potentially toxic agents,and silk fibroin microspheres could be prepared at normal temperature and pressure,and it′s easy to expand production." @default.
- W2382108889 created "2016-06-24" @default.
- W2382108889 creator A5073693142 @default.
- W2382108889 date "2013-01-01" @default.
- W2382108889 modified "2023-09-23" @default.
- W2382108889 title "Studies on the preparation technology of Metformin Silk Fibroin Microspheres" @default.
- W2382108889 hasPublicationYear "2013" @default.
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