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- W2382125588 abstract "AIM AND METHODS The effects of losartan (after operation 2 week to 10 week, 5 mg/kg d ig) on generation of AT1R-AA in sera were observed during development of hypertension in rats. The renovascular hypertension (RVH) model was established by two-kidney one-clip method, a synthetic peptide corresponding to amino acid sequence 165-191 of the second extracellular loop of the angiotensin II-1 receptor (AT1R) was used as antigen, SA-ELISA were used to examine sera AT1R autoantibody (AT1R-AA). RESULTS The frequencies and titres of AT1R-AA after operation one week rats were significantly increased (P < 0.05). The treatment with losartan not only inhibited structural and functional changes, but also the frequencies and titres of AT1R-AA was significantly lower (P < 0.05) than RVH group. CONCLUSION It is suggested that the losartan significantly inhibits generation of the AT1R-AA." @default.
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- W2382125588 date "2003-02-01" @default.
- W2382125588 modified "2023-09-24" @default.
- W2382125588 title "[Effect of losartan on produce of sera autoantibodies to angiotensin II-1 receptor in renovascular hypertension rats]." @default.
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