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- W2382134410 abstract "OBJECTIVE To explore the destructive effect of ambroxol coordinated with vancomycin on the biofilm of Staphylococcus aureus.METHODS The in vitro model of S.aureus biofilm was constructed;two-fold dilution method was adopted to assay the minimum inhibitory concentration;the scanning electron microscope(SEM)was used to observe the biofilm;MTT assay was used to estimate the bacterial counts.RESULTS As for the 3 d or 7 d biofilm,after being reacted with ambroxol for 24 hours,the biofilm of the ambroxol group was significantly less than the control group observed by SEM,biofilm bacterial counts indicated that the bacterial counts of S.aureus under the effect of vancomycin for 3d and under the effect of ambroxol plus vancomycin were(19.14±5.64)×107CFU/ml,(6.44±1.53) ×107CFU/ml and(3.13±0.95)×107CFU/ml,(43.28±3.74)×107CFU/ml,(27.39±4.97),and(17.61±2.14)×107CFU/ml under the effect for 7 d,which were significanty less than the control group(P0.01),the bacterial counts of the ambroxol plus vancomycin group was significantly less than that of the vancomycin group(P0.01).CONCLUSION Ambroxol can destroy the biofilm having been formed by S.aureu,as combined with vancomycin,it can significantly reduce S.aureus inside the biofilm,which demonstrates the synergetic bactericidal effect." @default.
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- W2382134410 date "2012-01-01" @default.
- W2382134410 modified "2023-09-23" @default.
- W2382134410 title "Effect of ambroxol in combination with vancomycin on biofilm of Staphylococcus aureus" @default.
- W2382134410 hasPublicationYear "2012" @default.
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