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- W2382135039 abstract "Objective To explore the inhibitory effect of melatonin(MT) on expression of glial fibrillary acidic protein in infant rats with brain injury induced by lipopolysaccharide(LPS).Methods One hundred and sixty Spragne-Dawley rats(1 month) were randomly divided into 4 groups:9 g/L saline group(NS group),LPS group,MT protective A group(MT plus LPS,MT was given 15 minutes earlier),and MT protective B group(MT plus LPS,MT was given immediately).Forty rats in each group,then every group was subdivided into 2 subgroups according to observe time point at 24 h and 48 h with 20 rats,respectively.Half of them in all subgroups were not injected Evans blue(EB).Rats were sacrificed at 2 time points to take brain tissue samples,respectively.EB content of brain tissue was meteraged by the formamide methods.Immunohistochemistry technology and computer assisted image analysis system methods were applied to observe the expression of the positive apoptosis cell of brain tissue.Results Both EB content and the expression of GFAP showed significant difference between LPS group and NS group(Pa0.01);The expression of positive GFAP area and EB content in MT protective groups were much higher than those in NS group (Pa0.01);The expression of positive GFAP area and EB content in MT protective groups were significantly lower than those in LPS group (Pa0.01);The expression of positive GFAP area and EB content in MT protective subgroups were not significantly different (P0.05).Conclusions LPS can induce the expression of GFAP in infectious brain injury of rats induced by LPS,and MT can inhibit the expression of GFAP;MT may play a role in dealing with infectious brain injury." @default.
- W2382135039 created "2016-06-24" @default.
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- W2382135039 date "2009-01-01" @default.
- W2382135039 modified "2023-09-26" @default.
- W2382135039 title "Inhibitory Effect of Melatonin on Expression of Glial Fibrillary Acidic Protein in Infant Rats with Brain Injury Induced by Lipopolysaccharide" @default.
- W2382135039 hasPublicationYear "2009" @default.
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