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- W2382138857 abstract "Objective:To explore the feasibility of radioimmunotherapy of human bone sarcoma xenograft with (131)I anti VEGF monoclonal antibody (Sc-7269) through studying the biodistribution of (131)I-Sc-7269 in human bone sarcoma xenograft and to compare the difference of system administration and local administration.Methods:Sc-7269 was labeled with (131)I by the Iodogen method.24 nude mice bearing human bone sarcoma xenografts were used for the biodistribution study after intratumoral injection (n=12) or intravenous injection (n=12) of (131)I-Sc-7269.Results: (131)I-Sc-7269 could selectively aggregate in tumor,whatever approach was used.And compared with systemic administration,local administration of (131)I-Sc-7269 produced prolonged higher tumor radioactivity with lesser normal tissue uptake.Conclusion: (131)I-Sc-7269 has a considerable targeting activity,and local administration is preferable in biodistribution." @default.
- W2382138857 created "2016-06-24" @default.
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- W2382138857 date "2005-01-01" @default.
- W2382138857 modified "2023-09-24" @default.
- W2382138857 title "Experimental Study on Biodistribution of ~(131)I-Labeled Anti-VEGF Monoclonal Antibody in Human bone Sarcoma Xenograft:System Administration Compared with Local Administration" @default.
- W2382138857 hasPublicationYear "2005" @default.
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