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- W2382140801 abstract "A LC-MS/MS method was established for the determination of hydrochlorothiazide in human plasma. Pharmacokinetics after oral administration of candesartan cilexetil hydrochlorothiazide tablets in 20 healthy volunteers was investigated.The calibration curve of hydrochlorothiazide was linear in the concentration range of 1-200ng/ml.The pharmacokinetic parameters of single oral doses of 12.5 and 25mg were as follows:C_(max)(74.14±15.04)and(125.57±23.47)ng/ml,t_(max)(1.85±0.53)and(2.20±0.59)h,t_(1/2)β(11.57±2.39)and(10.93±1.71)h,AUC_(0→48h)(470.0±90.7)and(794.7±182.6)h·ng·ml~(-1),respectively.The pharmacokinetic parameters at steady state were t_(max)(1.83±0.25)h,C_(max)~(ss)(80.21±17.98)ng/ml,C_(min)~(ss)(3.72±1.79)ng/ml,c_(av)(19.37±3.20)ng/ml,AUC_(0→48h)(484.90±76.89)h·ng·ml~(-1),respectively." @default.
- W2382140801 created "2016-06-24" @default.
- W2382140801 creator A5047257967 @default.
- W2382140801 date "2009-01-01" @default.
- W2382140801 modified "2023-09-25" @default.
- W2382140801 title "Determination of Hydrochlorothiazide in Human Plasma by LC-MS/MS and Its Pharmacokinetics" @default.
- W2382140801 hasPublicationYear "2009" @default.
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