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- W2382142823 abstract "Objective To establish an ultra performance liquid chromatography coupled with tandem mass spectrometry(UPLC-MS/MS) method for the determination of mitiglinide in human plasma,and to apply it in pharmacokinetic study.Methods A total of 24 healthy volunteers(12 males and 12 females) were randomly divided into 3 group:each group was administered 5,10,and 20 mg,respectively.Blood samples were collected before and after the administration of mitiglinide and were frozen at-70 ℃ until analysis.Nateglinide was used as the internal standard.The plasma samples were extracted by protein precipitation with acetonitrile.The fractions were injected into ACQUITY UPLC BEH C18(50 mm×2.1 mm,1.7 μm),and the column temperature was 40 ℃.The mobile phase was composed of acetonitrile and 0.1 % formic acid(58∶42,v/v) at 0.25 mL·min-1.The compound was ionized in the turbo elec-trospray ionization(ESI) ion source of the mass spectrometer and was detected in the multiple reaction monitoring(MRM) mode.Results The calibration curve was linear at 10.0-7 000.0 ng·mL-1 for mitiglinide,R2=0.999 8.The extraction recovery was 88.89%-111.0%.The methodology recovery ranged 92.9%-100.5%.The intra-and inter-day RSDs were less than 12.3%.There were no significant differences in t1/2 and tmax among the 3 dosages within the studied dose range.The absorption of mitiglinide(Cmax and AUC0-8) showed linear relationship with the dose.The mean drug plasma concentration-time curve of mitiglinide after a single dose oral administration of mitiglinide coincided with the process of first-order kinetics.Conclusion UPLC-MS/MS is simple,accurate and suitable for the study of the pharmacokinetics of mitiglinide.Linear pharmacokinetic parameters are found after a single oral dose of mitiglinide." @default.
- W2382142823 created "2016-06-24" @default.
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- W2382142823 date "2010-01-01" @default.
- W2382142823 modified "2023-09-25" @default.
- W2382142823 title "UPLC-MS/MS determination of mitiglinide tablets in human plasma and its pharmacokinetics" @default.
- W2382142823 hasPublicationYear "2010" @default.
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