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- W2382145051 abstract "Objective To investigate the effect of chronic hypoxia on the vascular remodeling and contractile response to 5-HT on pulmonary arterial rings.Methods A rat pulmonary arterial hypertension model was established by chronic hypoxic exposure.The rats from normoxic(NOR)and chronic hypoxic(CH)group were assessed by measuring the hemodynamic parameters,such as RVSP,RVP and dp/dtmax,as well as by examining the weight ratio of right ventricle to left ventricle plus septum.Moreover the pathological changes of lung sections(H-E stained)were observed under light microscope.Tension studies of PA rings by organ bath technique was introduced to observe the effect of 5-HT-induced contraction on NOR and CH pulmonary arterial rings.The effect of different Ca2+ channel blocking agents on 5-HT-induced contraction was examined.Results After 3~4 weeks exposure to hypoxia,the mRVSP,mRVP,dp/dtmax and the weight ratio were significantly increased in CH group rats(P0.01).The tunica media of pulmonary artery from CH group was significantly thickening,and in a dose-dependent manner,a significant increase in 5-HT induced vasoconstriction response of pulmonary arterial rings can be observed from the same group.The inhibitory effect of 30 μmol/L La3+ on precontracted rings with 30 μmol/L 5-HT was significantly increased in CH rats(P0.01).However there is no significant difference for the inhibitory effect of a 30 μmol/L SKF96365 treatment between the two group rats.Conclusions A 3~4 weeks exposure to hypoxia could induce pulmonary hypertension and increase vascular contractile response to 5-HT.Store-operated calcium channels of pulmonary artery that up-regulated by chronic hypoxia may contribute to the hyperreactivity to 5-HT in CH-rats." @default.
- W2382145051 created "2016-06-24" @default.
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- W2382145051 date "2009-01-01" @default.
- W2382145051 modified "2023-09-25" @default.
- W2382145051 title "Chronic Hypoxia Leads to a Left Shift in 5-HT-Induced Concentration-Dependent Vasoconstriction Curve in Rats" @default.
- W2382145051 hasPublicationYear "2009" @default.
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