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- W2382149092 abstract "Objective To study the total content and activity of cytochrome P450(CYP450) in rat liver induced by digoxin in combination with amlodipine,and to evaluate their availability and safety for rational administration in clinic.Methods Male rats were randomly administrated with drugs(0.5%CMC-Na,digoxin,amlodipine,digoxin co-administration with amlodipine) respectively for seven days,once a day.After seven days,the total content of CYP450 and the activities of aminopyrine-N-demethylase(ADM),erytheomycin-N-demethylase(ERD) and coumarin-7-hydroxylation were determined in liver,alanine aminotransferase(ALT) was studied in serum.Results Digoxin at 0.05 mg,amlodipine at 1.0 mg and co-administration of digoxin and amlodipine all had significant inhibitory effect on ERD,but it exhibited no inhibitory action on ADM and 7-CH after oral administration for seven days in rat.Compared with digoxin or amlodipine,co-administration of digoxin and amlodipine showed no more inhibitory effect on ERD.Conclusion Co-administration of digoxin and amlodipine showed no significant drug interaction,which not changing the drug efficacy and increasing incidence of adverse drug reaction." @default.
- W2382149092 created "2016-06-24" @default.
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- W2382149092 date "2008-01-01" @default.
- W2382149092 modified "2023-09-24" @default.
- W2382149092 title "Effects of digoxin in combination with amlodipine on CYP450 in rat liver microsomes" @default.
- W2382149092 hasPublicationYear "2008" @default.
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