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- W2382149462 abstract "Objective To investigate the role of P-selectin,intercellular adhesive molecule-1(ICAM -1) and dendritic cells(DCs) in rat kidney with renal ischemia-reperfusion injury, as well as the preventive effect of anti-P-seleclin lectin-ECF domain monoclonal antibody (PsL-ECFmAb) .Methods Rat models of renal ischemia - reperfusion were established, which were divided into treated group with PsL - EGF mAb( n = 20) and untreated group(n = 20), which included 4 groups repectively according to reperfusion time (1, 3, 6, 24h) ,sham group(n = 5)served as control. DCs were observed by microscopy image method, while P-selectin and ICAM - 1 were analysed by immunohistochemistry LSAB, and MDA contents, SOD activities and cell apoptosis were detected at the same time. Results (1)P-selectin presented was increased evidently in renal tubular epithelial cell alter ischemia-reperfusion 1h, and the expression of ICAM - 1 was up - regulated in renal vessels after 6h.(2)CD1a+CD80+DC was gradually found in renal tubules and interstitium from ischemia - reperfusion 1h , and number of DCs of 24h group is greater than others. The localization of DCs was associated with rat blood uria nitrogen and serum creatinine(P 0.05) .(3)Increased MDA contents, declined SOD activities and cell apoptosis were found in renal tissues following rat renal ischemia-reperfusion injury.(4)These changes became less conspicuous in rat treated with PsL - EGFmAb. Conclusions DCs play an important role in immune pathogenesis of renal ischemia-reperiusion injury. PsL - ECFmAb may adjust and inhibit local DCs immigration and accumulation of kidney." @default.
- W2382149462 created "2016-06-24" @default.
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- W2382149462 date "2003-01-01" @default.
- W2382149462 modified "2023-09-22" @default.
- W2382149462 title "Effect of Anti-adhesive Treatment on Dendritic Cell Immigration and Accumulation in Rat Renal Ischemia-reperfasion Injury" @default.
- W2382149462 hasPublicationYear "2003" @default.
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