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- W2382156911 abstract "Objective To evaluate in vivo depiction and tracking for magnetically labeled bone marrow mesenchymal stem cells (MSCs) in a renal failure rat model injected intravascularly using a 1.5 T magnetic resonance imaging(MRI) system. Methods Rat MSCs were isolated, purified, expanded and then incubated with home synthesized Fe_2O_3-PLL. Prussian blue stain was employed for identifying intracellular irons. An acute renal failure in rat was induced by intramuscular injection of glycerol and MSCs were injected into renal arteries of 11 recipients (labeled cells in six, unlabeled cells in five). MR images of kidneys were obtained respectively before injection of MSCs, and immediately, 1, 3, 5, and 8 days after transplantation. MR imaging findings were analyzed, which were correlated with histological findings. Results Rat MSCs were successfully labeled, and labeling efficiency was almost 100%. Prussian blue staining of Fe_2O_3-PLL labeled cells revealed the presence of iron-containing vesicles or endosomes in the cytoplasm. In the renal failure model of rats, the labeled MSCs were demonstrated as signal intensity loss in renal cortex on T_2*-weighted MR images. The signal intensity decrease was visualized up to days 8 after transplantation. Histological analyses showed that most Prussian blue staining-positive cells were well correlated with the area where a signal intensity loss was observed in MRI. Signal intensity decrease was not detected after transplantation of unlabeled cells.Conclusion The rat MSCs can be effectively labeled with Fe_2O_3-PLL. 1.5-T MR imaging seems to be a good technique to monitor the magnetically labeled MSCs in vivo in renal failure rat model intravascularly administered, which may have much more potential values for studying the engraftment of stem cells in kidneys." @default.
- W2382156911 created "2016-06-24" @default.
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- W2382156911 date "2006-01-01" @default.
- W2382156911 modified "2023-09-24" @default.
- W2382156911 title "In vivo tracking of magnetically labeled mesenchymal stem cells injected via renal arteries in kidney failure rat" @default.
- W2382156911 hasPublicationYear "2006" @default.
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