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- W2382156931 abstract "Objective To investigate photoreceptor apoptosis and gene regulation in hereditary retinal degeneration of Royal College of Surgeon (RCS) rats. Methods The retinal sections of RCS rats of different ages were examined by a light microscope, TUNEL and Bc1-2 protein immunohistochemical method. Results Compared with age matched SD rats, the photoreceptor cells (PRC) in RCS rats, 15 days after birth, showed outer segment membrane accumulation, inner segment disorder, nuclei pycnosis, and cell disappearance. PRC death peaked at postnatal day 30 to 40. From 25 to 40 days, the nuclei of PRC in RCS rats were stained positively by TUNEL and the retina at day 35 had the largest amount of stained nuclei. Positive staining of Bcl-2 protein could be seen in the ganglion cell layer and the inner nuclear layer from 30 to 40 days, and showed the most in the inner nuclear layer at 30 days. No obvious positive granules could be detected in the Outer nuclear layer at any ages. Conclusion It is through apoptosis that PRCs die in hereditary retinal degeneration of RCS rats. Bcl-2 protein might not have a role in the regulation of photoreceptor apoptosis." @default.
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- W2382156931 date "2006-03-01" @default.
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- W2382156931 title "Photoreceptor Apoptosis and Bc1-2 Expression in Inherited Retinal Degengration of RCS Rats" @default.
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