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- W2382164054 abstract "AIM: To determine whether the cardiac structural and functional changes are related to the genesis of cardiac receptor auto-antibodies (auto-Ab). METHODS: In two rat models with failing heart induced by clipping aorta and injection of doxorubicin, the dynamic changes of serum auto-Ab against cardiac β 1 - and M 2 - receptor were examined by SA-ELISA assay using synthetic receptor peptide as an antigen. RESULTS:(1) The frequencies and titers of both auto-Ab in these two models were all in low level before treatment. After treatment, the frequencies of both auto-Ab were significently increased in both models ( P0.01 ) and the titers of both auto-Ab were also greatly heightened( P 0 01).(2) Positive correlations were existed between cardiac structural and functional changes, and the titers of auto-Ab.(3) The generated auto-Ab underwent a gradual fading automatically within a period of several weeks. CONCLUTION: Cardiac structural and functional changes promoted the genesis of auto-Ab of cardiac β 1-and M 2-receptor ." @default.
- W2382164054 created "2016-06-24" @default.
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- W2382164054 date "1999-01-01" @default.
- W2382164054 modified "2023-09-23" @default.
- W2382164054 title "Relation of cardiac structural and functional changes to the genesis of cardiac receptor auto-antibodies" @default.
- W2382164054 hasPublicationYear "1999" @default.
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