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- W2382174544 abstract "Objective To study the variation of c-fos expression in wound margin tissue of human chronic wounds before and after treatment of vacuum-assisted closure. Methods Tissues of chronic wound margin were taken from 5 patients before and 1,4,7 days after vacuum-assisted closure. The ABC immunohistochemical method was used to characterize the gene product expressions of c-fos in the above mentioned tissue. Results The number of c-fos positive cells before vacuum-assisted closure were more than after it. The signals of c-fos were localized mainly in nuclei of basal layer cells, dermal fibroblasts and inflammatory cells and less in cytoplasms. With the prolonging of vacuum-assisted closure time, the number of c-fos positive cells located mainly in dermal fibroblasts became less and less with the least expression in day 7. Conclusion C-fos may play an important role in the course of promoting wound healing by vacuum-assisted closure and also high expression of c-fos maybe a crucial factor in the formation of chronic wound." @default.
- W2382174544 created "2016-06-24" @default.
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- W2382174544 date "2002-01-01" @default.
- W2382174544 modified "2023-09-24" @default.
- W2382174544 title "Effect of vacuum-assisted-closure on c-fos expression in human chronic wound" @default.
- W2382174544 hasPublicationYear "2002" @default.
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