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- W2382175028 abstract "Objective To study the possibility of monocyte chemotactic protein 1 monoclonal antibody(MCP 1 McAb) or Losartan antagonizing the proliferation and migration of cultured vascular smooth muscle cells (VSMCs) mediated by angiotensin Ⅱ(AngⅡ). Methods The cultured VSMCs were divided into 5 groups, i.e. 2% fetal calf serum group (2%FCS group), AngⅡ group (concentration of 10 -10 -10 -6 mol/L), Losartan group (concentration of 10 -7 -10 -5 mol/L), MCP 1 McAb group(final concentration of 10 μg/ml) and positive control (concentration 5% zymosan). The migration effects of cultured VSMCs were examined by a modified Boyden's chamber. And the proliferation effect was evaluated with MTT, thiazolyl blue intaking, 3H TdR and 3H proline incorporation as well as VSMCs count. Results ①AngⅡexerted an enhancing effect on the proliferation and migration of cultured VSMCs in a concentration dependent manner; ②Both MCP 1 McAb and Losartan could antagonize the proliferation and migration of AngⅡ mediated VSMCs. Conclusion It is suggested that MCP 1 McAb and Losartan both play predominant roles in inhibiting the proliferation and migration of VSMCs and are prospective in the treatment of atherosclerotic diseases." @default.
- W2382175028 created "2016-06-24" @default.
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- W2382175028 date "2000-01-01" @default.
- W2382175028 modified "2023-09-27" @default.
- W2382175028 title "Antagonistic effect of MCP-1 McAb and Losartan on proliferation and migration of Ang-II-mediated VSMCs in vitro" @default.
- W2382175028 hasPublicationYear "2000" @default.
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