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- W2382177599 abstract "Objective To study the skeletal effects of Bugu capsule and etidronate in orchiectomized(ORX) rats by bone histomorphometry. Methods Forty three-and-half-month-old Sprague Dawley male rats were randomly divided into four groups: aging control(sham), orchiectomized group(ORX), ORX with etidronate group and ORX with Bugu capsule group. Group Sham and ORX with 0.9% Nacl daily, the other two groups were injected through mouth with etidronate 36 mg/kg·d and Bugu capsule 5 mL/kg per day (330 g/kg) respectively. After 90 days, all rats were sacrificed and their proximal tibial(PTM)were processed into undecalcified sections for histomorphometric analysis. Results Compared with sham control, ORX group manifested reduction of bone mass (percent trabecular area%Tb.Ar -50.7% , P0.05). Indexes of bone formation and bone resorption rate both increased markedly.%Tb.Ar increased by 54.0% (P0.05) in Bugu group and by 86.1%(P0.05) in etidronate treatment group compared with that of ORX. Dynamic data showed that bone formation and resorption rate both reduced, but with no significance between two groups. Conclusions The results indicate that the Bugu capsule could prevent the bone loss in ORX rats as well as etidronate." @default.
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- W2382177599 date "2007-01-01" @default.
- W2382177599 modified "2023-09-24" @default.
- W2382177599 title "The effect of Bugu capsule and etidronate on bone metabolism in orchiectomized(ORX) rats" @default.
- W2382177599 hasPublicationYear "2007" @default.
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