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- W2382185862 abstract "OBJECTIVE To investigate the plasma total homocysteine(tHcy) in the patients with chronic renal failure(CRF) and the relationship between plasma tHcy level and levels of serum folic acid and vitaminB _12(VitB _12). METHODS Levels of plasma tHcy of 45 CRF patients and 40 normal subjects were determined using fluorescence polarization immunoassay(FPIA),serum folic acid concentrations were measured by ion capture immunoassay(ICIA),and serum VitB _12 concentrations were measured by microparticle enzyme immunoassay(MEIA). RESULTS The mean level of tHcy in the CRF patients (24±12)μmol·L_-1 was significantly higher than that in the normal controls(_8.0±_2.9)μmol·L_-1(P_0.01). The mean level of serum folic acid in the CRF patients (18±_6.3)nmol·L_-1 was significantly lower than that in the normal controls(21±_8.3)nmol·L_-1 (P_0.01),and the level of serum VitB _12 in the CRF patients(423±154)pmol·L_-1 was significantly lower than that in the normal controls(485±181)pmol·L_-1 (P_0.01). Correlation analysis showed that plasma tHcy was negatively correlated with serum folic acid and VitB _12 in CRF group,and in normal group. CONCLUSION Hyperhomocysteinemia is more prevalent in the patients with CRF,deficiency of folic acid and VitB _12 is an important factor of inducing hyperhomocysteinemia." @default.
- W2382185862 created "2016-06-24" @default.
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- W2382185862 date "2004-01-01" @default.
- W2382185862 modified "2023-09-26" @default.
- W2382185862 title "Plasma homocysteine to serum folic acid and vitamin B_(12) in patients with chronic renal failure" @default.
- W2382185862 hasPublicationYear "2004" @default.
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