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- W2382191049 abstract "OBJECTIVE:To explore the clinical value of serum CEA,OPN,CA19-9and NSE in gastrointestinal neuroendocrine neoplasm.METHODS:The serum from 56patients with gastrointestinal neuroendocrine neoplasm was collected and tumor markers CEA,CA19-9and NSE was detected with electrochemiluminescence method,and OPN was detected with Enzyme-linked immunosorbent assay method,and was compared with 30cases benign gastrointestinal disease and 30health controls.RESULTS:The serum levels of CEA,OPN,CA19-9and NSE in gastrointestinal neuroendocrine neoplasm patients were(39.22±21.21)ng/mL,(156.51±42.23)ng/mL,(58.13±13.42)U/mL,and(37.21±12.78)ng/mL,which were significantly higher than those in the benign gastrointestinal disease(2.71±2.01)ng/mL,(30.12±8.91)ng/mL,(13.12±6.23)U/mL and(10.47±4.87)ng/mL and healthy control group(2.57±1.43)ng/mL,(28.89±7.92)ng/mL,(12.72±6.74)U/mL and(9.11±3.19)ng/mL(P0.01).The serum levels of CEA,OPN,CA19-9and NSE in gastrointestinal neuroendocrine neoplasm patients in postoperation were(21.34±11.34)ng/mL,(89.27±21.78)ng/mL,(38.27±7.23)U/mL and(22.41±7.28)ng/mL,which were lower than those in preoperation(39.22±21.21)ng/mL,(156.51±42.23)ng/mL,(58.13±13.42)U/mL and(37.21±12.78)ng/mL(P0.01).The serum levels of CEA,OPN,CA19-9and NSE in gastrointestinal neuroendocrine neoplasm patients had a positive correlation with the tumor histological types,grading,clinical stage and lymphnode metastas(P0.05)and had not related to patient age,sex,tumor site.The sensitivity of the CEA,CA19-9 and NSE three tumor markes in combination was 96.43%,specificity was 85.00%,accuracy was 90.52%,and negative predictive value was 96.23%.CONCLUSION:The dynamic combined detection of CEA,CA19-9and NSE three tumor markes are better prewarning markers for monitoring their recurrence and metastasis of gastrointestinal neuroendocrine neoplasm,and benefit to early diagnosis and interference." @default.
- W2382191049 created "2016-06-24" @default.
- W2382191049 creator A5064176890 @default.
- W2382191049 date "2013-01-01" @default.
- W2382191049 modified "2023-09-23" @default.
- W2382191049 title "Combination of serum biomarkers for diagnosis of gastroenteropancreatic neuroendocrine neoplasm" @default.
- W2382191049 hasPublicationYear "2013" @default.
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