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- W2382197707 abstract "OBJECTIVE To prepare oxaprozin solid dispersions. METHODS The oxaprozin solid dispersions with PEG 6000 as carrier were prepared by melting method. The paddle method was used for dissolution test. The structural analysis was made by X-ray diffraction. RESULTS The oxaprozin-PEG 6000 solid dispersion was a simple-lower-eutectic compound. The oxaprozin was dispersed in PEG 6000 as micro-crystallite form. The content of oxaprozin in all the solid dispersions (1∶5,1∶7,1∶9,1∶11) were in the range of 98%-106%. The dissolution rate of the solid dispersions was markedly increased in comparison with that of the physical mixture and oxaprozin substance (P 0.01). The higher the weight ratio of PEG 6000,the faster the solid dispersions dissolved. CONCLUSION The oxaprozinPEG 6000 solid dispersions dissolve much more rapidly in vitro and can be used to prepare the oxaprozin preparations with high clinic effect." @default.
- W2382197707 created "2016-06-24" @default.
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- W2382197707 date "2005-01-01" @default.
- W2382197707 modified "2023-09-26" @default.
- W2382197707 title "Study of oxaprozin solid dispersions" @default.
- W2382197707 hasPublicationYear "2005" @default.
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