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- W2382201401 abstract "Objective To investigate the effect of capsaicin (CAP) on kainate (KA)-evoked responses in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN). Methods Nystatin-perforated patch-recording configuration under voltage-clamp conditions was employed.Results The responses to KA were mediated by the activation of theα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in SDCN neurons.CAP reversibly inhibited KA (100μmol/L)-activated currents (I_(KA)) in a concentration-dependent manner over the concentration range of 10μmol/L to 3 000μmol/L with the IC_(50) value of (60.7±19.2)μmol/L at a holding potential of-40 mV.Our further study indicated that the effects of CAP on I_(KA) were voltage-independent.Moreover,the inhibition was not use-dependent and not overcomed by increasing the concentration ofagonist.Conclusion CAP is an efficacious inhibitor of AMPA receptor-mediated responses,which may contribute to the modulation of visceral pain." @default.
- W2382201401 created "2016-06-24" @default.
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- W2382201401 date "2007-01-01" @default.
- W2382201401 modified "2023-09-25" @default.
- W2382201401 title "Suppression of AMPA receptor-mediated currents by capsaicin in rat sacral dorsal commissural neurons" @default.
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