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- W2382202460 abstract "OBJECTIVE To investigate the compatibility of fluorouracil implants and protein-denaturant hydrochloric acid (PDHA).METHODS 96 Tubes of the implants and PDHA were kept at the(37±0.5)℃.Six samples were collected at 1,25,49, 73,97,121 h after incubation.Appearance of the implants was observed by microscope.Stability of fluorouracil in PDHA was deter- mined by HPLC and ultraviolet absorb method,quantity of fluorouracil in the implants and saturated concentration of fluorouracil in PDHA were determined by ultraviolet absorb method.According to entering quantity and residual quantity of fluorouracil,the release degrees were calculated.RESULTS At(37±0.5)℃,the fluorouracil was stable for 960 h in PDHA,the saturated concentration of fluorouraeil was(22.72±0.04)g·L~(-1).The appearance of implants was completed.Many bores at surface.Compared with the speed of release drug in rats,the speed of release drug was faster in the first half of release process and slower in the last haft of release process.The drug was released incompletely.During the period of 1,96,360 and 960 h,the implants release degrees were(11.9±5.3)%,(52±4.3)%,(75.3±3.8)% and(85.3±2.1)%,respectively.CONCLUSION The fluorouracil is stable in PDHA 960 h at(37±0.5)℃.The fluorouracil implants and 6 mol·L~(-1)hydrochloric acid are compatible and no influence was detected during the observation." @default.
- W2382202460 created "2016-06-24" @default.
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- W2382202460 date "2008-01-01" @default.
- W2382202460 modified "2023-09-23" @default.
- W2382202460 title "Study on Behavior of Fluorouracil Implants in Protein Denaturant Hydrochloric Acid" @default.
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