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- W2382204525 abstract "Objective To observe the effect of edaravone pretreatment on cognitive fuction of Alzheimer-type model rats and to investigate the mechanism.Methods 48 adult male SD rats were divided into 4 groups randomly:Sham group(S),Edaravone+Sham group(E+S),ICV-STZ Lesion group(L),and Edaravone+Lesion group(E+L).The learning and memory performance was assessed using Morris water maze test.The colorimetric method was used to evaluate the content of superoxide dismutase(SOD) and malonaldehyde(MDA) in rats'brain.The expression of Bcl-2 was estimated using immunohistochemical method.Results In Morris water maze test,compared with the S group,the spent time in target quadrant in L group was significantly decreased(P0.05),and the escape latency was significantly prolonged(P0.05).Compared with the L group,the spent time in target quadrant in E+L group was significantly increased(P0.05),and the escape latency was significantly decreased(P0.05).Compared with the L group,the SOD content in E+L group was significantly increased(P0.05),and the MDA content in E+L group was significantly decreased(P0.05).Compared with the the L group,the Bcl-2 expression in E+L group was significantly increased.Conclusion STZ induced cognitive impairment in rats was ameliorated by edaravone pretreatment.This beneficial effect was implemented by improving cerebral oxidative stress and reducing neuronal apoptosis." @default.
- W2382204525 created "2016-06-24" @default.
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- W2382204525 date "2011-01-01" @default.
- W2382204525 modified "2023-09-28" @default.
- W2382204525 title "The protective effect of edaravone on cognitive impairment and Bcl-2 expression in the model rats of Alzheimer type" @default.
- W2382204525 hasPublicationYear "2011" @default.
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