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- W2382205582 abstract "The development of resistance to anti-cancer therapies in bones is a major hurdle preventing long-lasting clinical responses to anti-cancer therapies in hormone refractory prostate cancer. Herein, we present the major signal transduction pathways, which are activated in prostate cancer cells residing at bone metastasis microenvironment. These intracellular signal transduction pathways can inhibit anti-cancer therapy-induced apoptosis of metastatic prostate cancer cells, thereby optimizing their survival, locally. Employment of this knowledge in a clinical setting provides the conceptual framework for the development of bone-targeted therapies for advanced prostate cancer. Indeed, bone metastasis microenvironment-targeted therapies illustrate a novel paradigm in cancer treatment: anti-tumor treatment strategies may not only aim at directly inducing cancer cell apoptosis, but can also target the tumor metastasis microenvironment, and neutralize the protection it confers on metastatic cancer cells." @default.
- W2382205582 created "2016-06-24" @default.
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- W2382205582 creator A5043391688 @default.
- W2382205582 creator A5048755230 @default.
- W2382205582 creator A5088291684 @default.
- W2382205582 date "2005-06-01" @default.
- W2382205582 modified "2023-09-26" @default.
- W2382205582 title "Prostate cancer cell survival pathways activated by bone metastasis microenvironment." @default.
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- W2382205582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15951629" @default.
- W2382205582 hasPublicationYear "2005" @default.
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