FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382207505> ?p ?o ?g. }

• W2382207505 endingPage "663" @default.
• W2382207505 startingPage "659" @default.
• W2382207505 abstract "OBJECTIVE To explore the impact of hydrogen sulfide (H2S) on the carbon monoxide (CO)/heme oxygenase-1 (HO-1) system in pulmonary artery of hypoxic rats. METHODS Twenty-seven rats were randomly divided into four groups: hypoxic group (n = 7), hypoxic + NaHS group (n = 7), hypoxic + propargylglycine (PPG) group (n = 6) and control group (n = 7). After 21 days, pulmonary artery mean pressure (mPAP) of each rat was evaluated and the plasma concentration of H2S and CO were measured. The expression of HO-1 in pulmonary arteries of each rat was detected by immunohistochemistry technique. In situ hybridization for HO-1 mRNA in pulmonary arteries was also observed. RESULTS mPAP was significantly increased in hypoxic rats [(20.5 +/- 2.9) mm Hg] as compared with that of normal controls [(14.8 +/- 3.6) mm Hg, P <0.05]. The plasma H2S[(196+/-22 ) micromol/L] of hypoxic group was decreased significantly compared with control group [(294+/-26) micromol/L, P < 0. 05]. The plasma CO and the expression of HO-1 protein and mRNA in large, medium and small sized pulmonary arteries of hypoxic group [ (0.348 +/- 0.021) micromol/L, 0.79+/-0.08, 0.77+/-0.08, 0.76+/-0.09, 0.813+/-0.052, 0.831+/-0.043, 0.819+/-0.032, respectively] were significantly increased compared to control rats [(0.313+/-0. 020) micromol/L, 0.66+/-0.08, 0.64+/-0.05, 0.54+/-0.05; 0.573 +/- 0.148, 0.532+/-0.131, 0.473+/-0.102, respectively; all P <0.05]. Compared with hypoxic group, the plasma H2S of hypoxic + NaHS group [(324+/-33 ) micromol/L] was significantly increased, and mPAP was decreased significantly (all P < 0.05). Meanwhile, compared with hypoxic group, the plasma concentration of CO [(0.393+/-0.032) micromol/L], the expression of HO-1 protein and mRNA in large, medium and small sized pulmonary arteries were significantly increased in hypoxic + NaHS group (0.88+/-0.04, 0.89 +/- 0.05, 0.89 +/- 0.06; 0.913 +/- 0.022, 0.922 +/- 0.021, 0.933 +/- 0.014, respectively; all P < 0.05). However, compared with hypoxic group, the plasma concentration of H2S was decreased significantly in hypoxic + PPG group [(142 +/- 45) micromol/L, P < 0. 05], and mPAP was increased significantly (P < 0.05). With the decrease of H2S in hypoxic + PPG group, the plasma concentration of CO, the expression of HO-1 protein and mRNA in large, medium and small sized pulmonary arteries were significantly decreased [(0.274 +/- 0.032) micromol/L; 0.54 +/- 0.06, 0.56+/-0.04, 0.39+/-0.06; 0.423 +/- 0.043, 0.418 +/- 0.091, 0.382+/-0.051 respectively; all P <0.05] compared to hypoxic group. CONCLUSION H2S upregulated CO/HO-1 system in pulmonary arteries of hypoxic rats." @default.
• W2382207505 created "2016-06-24" @default.
• W2382207505 creator A5010928387 @default.
• W2382207505 creator A5040992357 @default.
• W2382207505 creator A5049949051 @default.
• W2382207505 creator A5061457037 @default.
• W2382207505 date "2004-10-01" @default.
• W2382207505 modified "2023-09-28" @default.
• W2382207505 title "[The regulation of carbon monoxide/heme oxygenase system by hydrogen sulfide in rats with hypoxic pulmonary hypertension]." @default.
• W2382207505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16200866" @default.
• W2382207505 hasPublicationYear "2004" @default.
• W2382207505 type Work @default.
• W2382207505 sameAs 2382207505 @default.
• W2382207505 citedByCount "2" @default.
• W2382207505 countsByYear W23822075052012 @default.
• W2382207505 countsByYear W23822075052020 @default.
• W2382207505 crossrefType "journal-article" @default.
• W2382207505 hasAuthorship W2382207505A5010928387 @default.
• W2382207505 hasAuthorship W2382207505A5040992357 @default.
• W2382207505 hasAuthorship W2382207505A5049949051 @default.
• W2382207505 hasAuthorship W2382207505A5061457037 @default.
• W2382207505 hasConcept C104317684 @default.
• W2382207505 hasConcept C105580179 @default.
• W2382207505 hasConcept C126322002 @default.
• W2382207505 hasConcept C134018914 @default.
• W2382207505 hasConcept C161790260 @default.
• W2382207505 hasConcept C178790620 @default.
• W2382207505 hasConcept C181199279 @default.
• W2382207505 hasConcept C185592680 @default.
• W2382207505 hasConcept C2776217839 @default.
• W2382207505 hasConcept C2779219270 @default.
• W2382207505 hasConcept C2780564542 @default.
• W2382207505 hasConcept C2780930700 @default.
• W2382207505 hasConcept C2780940725 @default.
• W2382207505 hasConcept C512735826 @default.
• W2382207505 hasConcept C518881349 @default.
• W2382207505 hasConcept C540031477 @default.
• W2382207505 hasConcept C55493867 @default.
• W2382207505 hasConcept C71924100 @default.
• W2382207505 hasConcept C7836513 @default.
• W2382207505 hasConcept C81439078 @default.
• W2382207505 hasConceptScore W2382207505C104317684 @default.
• W2382207505 hasConceptScore W2382207505C105580179 @default.
• W2382207505 hasConceptScore W2382207505C126322002 @default.
• W2382207505 hasConceptScore W2382207505C134018914 @default.
• W2382207505 hasConceptScore W2382207505C161790260 @default.
• W2382207505 hasConceptScore W2382207505C178790620 @default.
• W2382207505 hasConceptScore W2382207505C181199279 @default.
• W2382207505 hasConceptScore W2382207505C185592680 @default.
• W2382207505 hasConceptScore W2382207505C2776217839 @default.
• W2382207505 hasConceptScore W2382207505C2779219270 @default.
• W2382207505 hasConceptScore W2382207505C2780564542 @default.
• W2382207505 hasConceptScore W2382207505C2780930700 @default.
• W2382207505 hasConceptScore W2382207505C2780940725 @default.
• W2382207505 hasConceptScore W2382207505C512735826 @default.
• W2382207505 hasConceptScore W2382207505C518881349 @default.
• W2382207505 hasConceptScore W2382207505C540031477 @default.
• W2382207505 hasConceptScore W2382207505C55493867 @default.
• W2382207505 hasConceptScore W2382207505C71924100 @default.
• W2382207505 hasConceptScore W2382207505C7836513 @default.
• W2382207505 hasConceptScore W2382207505C81439078 @default.
• W2382207505 hasIssue "10" @default.
• W2382207505 hasLocation W23822075051 @default.
• W2382207505 hasLocation W23822075052 @default.
• W2382207505 hasOpenAccess W2382207505 @default.
• W2382207505 hasPrimaryLocation W23822075051 @default.
• W2382207505 hasRelatedWork W2000157645 @default.
• W2382207505 hasRelatedWork W2015407072 @default.
• W2382207505 hasRelatedWork W2141610173 @default.
• W2382207505 hasRelatedWork W2348391417 @default.
• W2382207505 hasRelatedWork W2353491675 @default.
• W2382207505 hasRelatedWork W2356609832 @default.
• W2382207505 hasRelatedWork W2357867069 @default.
• W2382207505 hasRelatedWork W2362926168 @default.
• W2382207505 hasRelatedWork W2363578572 @default.
• W2382207505 hasRelatedWork W2364896453 @default.
• W2382207505 hasRelatedWork W2367986548 @default.
• W2382207505 hasRelatedWork W2371378333 @default.
• W2382207505 hasRelatedWork W2375698041 @default.
• W2382207505 hasRelatedWork W2376524607 @default.
• W2382207505 hasRelatedWork W2389617835 @default.
• W2382207505 hasRelatedWork W2392168873 @default.
• W2382207505 hasRelatedWork W2418983296 @default.
• W2382207505 hasRelatedWork W2467608898 @default.
• W2382207505 hasRelatedWork W2978545833 @default.
• W2382207505 hasRelatedWork W3031974617 @default.
• W2382207505 hasVolume "27" @default.
• W2382207505 isParatext "false" @default.
• W2382207505 isRetracted "false" @default.
• W2382207505 magId "2382207505" @default.
• W2382207505 workType "article" @default.