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- W2382220482 abstract "Objective To study the drug resistance mechanisms of Mycoplasma hominis(MH) against quinolone. Methods Ten strains of MH with three kinds of different quinolone resistance phenotype were isolated from urinary tract secretions. The DNA helicase gene sequence of the GyrA and GyrB in the ten isolates of MH with different phenotype resistance to quinolones and standard strain ATCC 23114 were detected. The sequencing results of the GyrA and GyrB were compared with wild-type strain PG21. Results Compared with wild strain (PG21), the S153-to-L substitution of GyrA, corresponding to Escherichia coli was S83-to-L substitutions, were found in 7 strains of isolates Mh resistant to Sparfloxacin, whereas the Mh isolates (No. 4) had S56-to-I substitutions. There was no amino acid residue mutation be found in the GyrA of Mh sensitive to Sparfloxacin and standard Mh strain. Conclusion The S83-to-L (corresponding to Escherichia coli number) substitution of GyrA was associated with Mh strains resistance to sparfloxacin." @default.
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- W2382220482 date "2010-01-01" @default.
- W2382220482 modified "2023-09-27" @default.
- W2382220482 title "Study on drug resistance mechanisms of mycoplasma hominis to quinolone." @default.
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