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- W2382223611 abstract "Objective:To investigate the quantity of Tregs/dendritic cells(DCs) and their corresponding PD-1/PD-L1 expression,and reveal the different functional status of both Tregs and DCs in patients with stable atherosclerosis or acute coronary syndrome.Method:The 39 patients with coronary heart disease(CHD) were enrolled,including 23 stable angina(SA) patients and 16 acute coronary syndrome(ACS) patients.Twenty non-CHD individuals proved by coronary angiography were selected as controls.The quantities of CD4+CD25+CD127lowPD-1+ T cells and CD11c+PD-L1+ DCs were determined by flow cytometry.The serum levels of IL-2 were measured by ELISA.Result:There was no significant difference of Treg quantity in CHD patients(including ACS and SA patients) and healthy controls.However,we found the expression of PD-1 on Tregs and PD-L1 on DCs in ACS patients were significantly down-regulated compared with SA and controls.Conclusion:Regulatory T cells may exhibit immune suppressive function via PD-1 molecule.Impaired function of Treg and DC may promote the progress of atherosclerosis and the vulnerability of plaque." @default.
- W2382223611 created "2016-06-24" @default.
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- W2382223611 date "2012-01-01" @default.
- W2382223611 modified "2023-09-23" @default.
- W2382223611 title "The quantity of peripheral regulatory T cells and the PD-1 expression in patients with coronary heart disease" @default.
- W2382223611 hasPublicationYear "2012" @default.
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