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• W2382227343 abstract "Objective To observe the intervention of methylene blue(MB), a guanylate cyclase inhibitor, on hemodynamics and visceral pathomorphology in rabbits with traumatic shock.Methods Eighteen rabbits was randomly assigned into 3 groups (n=6),namely control group, traumatic shock resuscitation with normal saline group (NS group) and traumatic shock resuscitation with methylene blue group (MB group). In NS group and MB group, TO record systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) at pre-shock, tele-shock, tele-resuscitation,0.5 hour,2 hours and 4 hours after resuscitation .In control group, SBP,DBP,MAP and HR were recorded in corresponding to courses of traumatic shock groups. Tissue samples of the liver and intestine obtained after experiments for microscopic examination.Results There weren't significant difference about basal SBP,DBP, MAP and HR among 3 groups (P0.05).In control group, there weren't significant difference about SBP,DBP, MAP and HR among all courses (P0.05). But in NS group, SBP,DBP,MAP and HR of tele-resuscitation and each after resuscitation time point vs basal all decreased(P0.05 or 0.01); there were significant difference about SBP,DBP and MAP of tele-resuscitation and each after resuscitation time point vs control group (P0.01); there were significant difference about HR of 2 hours and 4 hours after resuscitation vs control group (P0.05); there were significant difference about SBP,DBPand MAP of 2 hours after resuscitation vs MB group(P0.05 or 0.01).In MB group, there weren't significant difference about HR among all courses (P0.05); there weren't significant difference about HR among courses (P0.05) except for tele-resuscitation (P0.01)compared with control group; there weren't significant difference about SBP and MAP of tele-resuscitation compared with basal (P0.05) ,DBP and MAP of 4 hours after resuscitation were too not (P0.05); compared with control group, there weren't significant difference about MAP of tele-resuscitation and 4 hours after resuscitation(P0.05),SBP and DBP of 4 hours after resuscitation were too not (P0.05).In NS group, the pathologic lesions of the organs were very obvious. But in MB group, there were less pathologic lesions of the organs, and in control group, there weren't obviously pathologic lesions of the organs.Conclusions MB can obviously ameliorate hemodynamics of traumatic shock, and protect the important organs." @default.
• W2382227343 created "2016-06-24" @default.
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• W2382227343 date "2005-01-01" @default.
• W2382227343 modified "2023-09-25" @default.
• W2382227343 title "Intervention of methylene blue on hemodynamics and visceral lesion in rabbits with traumatic shock" @default.
• W2382227343 hasPublicationYear "2005" @default.
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