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- W2382234705 abstract "Objective To study the preventive effect of curcumin (Cur) on ultraviolet B (UVB) oxidation carcinogenesis in HaCaT cells and its mechanisms. Methods 1.25,2.50 and 5.00 mg·L-1 Cur were added into HaCaT cells irradiated by UVB and the cells were cultivated continually.The contents of oxides and antioxides were determined with zymochemistry method;the Δψ potential and the [Ca2+]i were measured with Rhodamine 123 and Fluo-3/AM fluorescence.The protein expressions of apoptotic correlating factors were examined by flow cytometry. Results Compared with control group,the Δψ of the HaCaT cells ,the contents of SOD and GSH-Px and the expression of Bcl-2 protein in UVB irradiation groups decreased significantly after UVB irradiation (P0.01);while the [Ca2+]i,the contents of ROS,NO and MDA,and the protein expressions of caspase-3,cytochrome c and Bax increased significantly (P0.01).After Cur was added into the cells irradiated with UVB , the Δψ and the expression of Bcl-2 in every Cur group increased significantly,the contents of SOD and GSH-Px in 2.50 and 5.00 mg·L-1 Cur groups increased significantly(P0.01),while the contents of ROS,NO and MDA and the protein expressions of caspase-3,cytochrom c and Bax in every Cur group and the [Ca2+]i in 2.50 and 5.00 mg·L-1 Cur groups decreased significantly compared with UVB irradiation group(P0.01).The ratio of Bcl-2/Bax varied within 0.58-2.50 and Cur showed a pattern of dose-effect.Conclusion Cur could increase the Δψ and the antioxidase activity and decrease the [Ca2+]i,the contents of oxides and the protein expressions of induced apoptotic correlating factors. Cur has preventive effect on cancinogenesis of the cells irradiated by UVB." @default.
- W2382234705 created "2016-06-24" @default.
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- W2382234705 date "2009-01-01" @default.
- W2382234705 modified "2023-09-25" @default.
- W2382234705 title "Preventive effect of curcumin on UVB oxidation carcinogenesis in HaCaT cells" @default.
- W2382234705 hasPublicationYear "2009" @default.
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