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- W2382244996 abstract "Objective To find the time and peak time that interferon(IFNs) inducer through nasal administration induce local mucous membrane of the respiratory tract to produce sufficient amounts of interferon,and whether continual medication can induce continual production of interferon.Methods Two interferon inducers,Poly I:C(group A) and Arbidol(group B) were dripped through nasal administration separately for 6 days(subgroup A1,sub-group B1),10 days(subgroup A2,subgroup B2),14 days(subgroup A3,subgroup B3) and 18 days(subgroup A4,subgroup B4).Then interferon content in animal nasal secretions was tested.Data was compared between group A(subgroup A1,A2,A3,A4) and group B(subgroup B1,B2,B3,B4),between subgroups A1,A2,A3,A4 as well as between subgroups B1,B2,B3,B4.Results(1) The detected interferon levels in nasal secretions of group A and group B were significantly higher than the control group(group C),P0.01.(2) The peak time of group A and group B was 10 days(subgroup A2,subgroup B2).There was significant difference between the subgroups(P0.01) except subgroup B2 and subgroup B3(P0.5).(3) The mice could adapt to nasal administration of reagents mentioned above perfectly,with no adverse reactions such as less activity,tiredness,eating less,bad-quality hair,biting,during the experiment.Conclusion Poly I:C and Arbidol can induce production of interferon in the mucous membrane of the respiratory tract trough nasal administration.The peak time of interferon content in nasal secretions induced by Poly I:C is 10 days,and that induced by Arbidol is 10~14 days.Continual medication can induce continual production of interferon." @default.
- W2382244996 created "2016-06-24" @default.
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- W2382244996 date "2013-01-01" @default.
- W2382244996 modified "2023-09-24" @default.
- W2382244996 title "Study on the timeliness of interferon induced by respiratory tract medication of Poly I:C and Arbidol" @default.
- W2382244996 hasPublicationYear "2013" @default.
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