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- W2382254471 abstract "Objective To study the alkaloid constituents of Zuojin Formula, consisting of Coptidis Rhizoma and Euodiae Fructus, and to evaluate their cytotoxicities against the proliferation of cancer cells in human digestive tract. Methods The constituents were isolated and purified by column chromatography on silica gel and Sephadex LH-20, as well as the chemical structures of alkaloids were determined by physicochemical properties and spectral data analyses. The cytotoxicities assay against human gastric NCI-N87 and colon adenocarcinoma Caco-2 cell lines was carried out by MTT method. Results Fifteen alkaloids were obtained from the normal butanol soluble fraction of 70% ethanolic extract in Zuojin Formula and identified as rutaecarpine(1), evodiamine(2), rhetsinine(3), coptisine(4), wuchuyuamide III(5), 8-trichloromethyl-7, 8-dihydropalmatine(6), epiberberine(7), 8-trichloromethyl-7, 8-dihydroepiberberine(8), 8-trichloromethyl-7, 8-dihydrocoptisine(9), palmatine(10), berberine(11), 1, 2, 3, 4-tetrahydro-1-oxo-β-carboline(12), noroxyhydrastinine(13), 8-oxo-epiberberine(14), and corydaldine(15). Compounds 1, 2, 4, and 11 showed the inhibitory activities against the proliferation of NCI-N87 and Caco-2 cell with the half inhibitory concentration of 12.61—91.18 μmol/L. Conclusion Compound 8 is a new compound. Compounds 1, 2, 4, and 11 may be the main effective components in Zuojin Formula against the proliferation of cancer cells in human digestive tract." @default.
- W2382254471 created "2016-06-24" @default.
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- W2382254471 date "2014-01-01" @default.
- W2382254471 modified "2023-09-23" @default.
- W2382254471 title "Alkaloids from Zuojin Formula and their cytotoxicities against proliferation of cancer cells" @default.
- W2382254471 hasPublicationYear "2014" @default.
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