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- W2382261237 abstract "【Objective】 The immunology activities of highly purified β-glucan extracted with alkali from fermented mycelia of Grifola frondosa strain GF-932 were tested.【Method】 The mycelia of G.frondosa was extracted with alkali and the crude polysaccharides were hydrolyzed with enzyme.Through the ultrafiltration,Sepharose column chromatography and lyophilization,the highly purified β-glucan was obtained.Size exclusion chromatography,liquid chromatography and software were used to determine and calculate relative molecular weight(RMW) and molecular weight distribution width of the β-glucan from mycelium,and the HPLC to assay the content of glucan.According to the recommended dose 2.5 mg/d of body mass(kg) per day in human,the G.frondosa β-glucan was formulated as a solution with sterile distilled water and administered to Specific Pathogen Free(SPF) mice at low-dose group(12.5 mg/d),middle-dose group(25.0 mg/d),high-dose group(75.0 mg/d) by gavage for 30 days.Control animals received equal volumes of sterile distilled water via the same administration.The influences of the β-glucan on the phagocytic indices phagocyte,the degree of paw swelling and the hemolysi splaque numbers by the test of clearance rate of carbon particles,delayed hypersensitivity test,and the antibody-producing cells assay was carried out respectively.The body mass and viscera index of mice was also measured.【Result】 The RMW and molecular weight distribution width of the high purified β-glucan was 136.43 ku and 1.64 respectively.Gavaged at different doses of β-glucan for 30 days,the body mass of mice in every group increased,but there were no differences(P0.05) between any of the treatment groups and the control.The highly purified alkali extracted β-glucan from G.frondosa can enhance the phagocytic indices of phagocyte,the degree of paw swelling and the hemolysi splaque numbers of mice,and increase the viscera index in mice.This indicates that the β-glucan has the function of raising the phagocytic ability of phagocyte,the function of cellular immunity and humoral immunity,and increasing the immunologic function of immuneorgan.【Conclusion】 The highly purified alkali extracted G.frondosa β-glucan can enhance evidently the immunocompetence of mice,including the phagocytic ability of phagocyte,the functions of the specifc immunity and the nonspecific immunity." @default.
- W2382261237 created "2016-06-24" @default.
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- W2382261237 date "2011-01-01" @default.
- W2382261237 modified "2023-09-24" @default.
- W2382261237 title "Study on immunology activities of high purified β-glucan alkali extracted from fermented mycelia of Grifola frondosa" @default.
- W2382261237 hasPublicationYear "2011" @default.
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