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- W2382263194 abstract "Objective To study the effects of matrine on the hemodynamics in Rats of Acute Myocardial Ischemic Injury.Methods Sprague-Dawley rats were divided into eight groups,i.e.,control,sham operation,AMI,Dan- shen+AMI,nitroglycerin+AMI,AMI+MT2.5mg/kg,5mg/kg,or 10mg/kg.Rat models of AMI were created by ligation left anterior descending coronary artery.At pre-occlusion and 5,15,30,60 min after left anterior descend- ing artery (LAD) occlusion,left ventricular systolic pressure (LVSP),left ventricular end diastolic pressure (LVEDP), +dp/dtmax and-dp/dtmax were measured.Results At 5,15,30,60 min after left anterior descending artery oc- clusion,LVSP,+dp/dtmax,-dp/dtmax were reduced(P0.05 or P0.01)and LVEDP was increased signifi- candy(P0.01)in AMI group.At 5,15,30,60 min after LAD occlusion,LVSP,+dp/dtmax,-dp/dtmax were increased(P0.05 or P0.01)and LVEDP was reduced significantly(P0.05 or P0.01)in AMI rats after MT administration at the dosage of 2.5 mg/kg,5 mg/kg,10 mg/kg.At 15,30 min after LAD occlusion,this function was obvious.The more rats got matrine,the longer the changes of parameters mentioned above lasted.Conclusion Intravenous matrine can improve the cardiac function." @default.
- W2382263194 created "2016-06-24" @default.
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- W2382263194 date "2008-01-01" @default.
- W2382263194 modified "2023-09-25" @default.
- W2382263194 title "Effects of Matrine on the Hemodynamics in Rats of Acute Myocardial Ischemic Injury" @default.
- W2382263194 hasPublicationYear "2008" @default.
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