Matches in SemOpenAlex for { <https://semopenalex.org/work/W2382291235> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2382291235 abstract "Aim To establish a permanent middle cerebral occlusion(pMCAO) model in spontaneously hypertensive rats(SHR) and investigate the neuroprotective effect of mild hypothermia therapy on neural lesion.Methods 33 SHR were randomly divided into four groups: 2 hours delayed mild hypothermia group;6 hours delayed mild hypothermia group,normal temperature group and sham group.The pMCAO model was established by suture-occluded method.Systemic mild hypothermia(33±0.5)℃ were induced on SHR 2 hours or 6 hours after pMCAO,and lasted for more than 30 hours.The objects were placed in room temperature(25℃).The neurological behavior impairment was evaluated at 5 hours,24 hours and 36 hours after the operation.All subjects were killed 36 hours after operation.Continuous coronal brain sections were stained by cresyl violet for the calculation of infarct volume and evaluation of brain edema.NeuN staining was used to detect the loss of neurons in the infarct and peri-infarct areas.Results There were no significant differences in neurological behavioral score among the ischemic groups.Compared with the control group,2 hours delayed mild hypothermia and 6 hours delayed mild hypothermia decreased infarct volume by 23.75%(P0.01) and 18.72%(P0.05),respectively.And the two mild hypothermic therapy alleviated brain edema by 25.32%(P0.05) and 21.52%(P0.05),respectively.In peri-infarct area,2 hours delayed mild hypothermia group and 6 hours delayed mild hypothermia group had an increased count of NeuN positive cells compared with the normal temperature group.The two different hypothermia therapies decreased Neuron loss by 21.67%(P0.01) and 15.67%(P0.05),respectively.In infarct core,no differences had been found in the number of NeuN positive cells among mild hypothermic groups and normal temperature group.There were no significant differences in infarct volume,brain edema and NeuN positive cells in peri-infarct area between the hypothermic groups.Conclusion Mild hypothermia could obviously decrease the infarct volume and brain edema after pMCAO.6 hours delayed mild hypothermia therapy had the similar function with 2 hours delayed mild hypothermia." @default.
- W2382291235 created "2016-06-24" @default.
- W2382291235 creator A5076459752 @default.
- W2382291235 date "2013-01-01" @default.
- W2382291235 modified "2023-09-24" @default.
- W2382291235 title "Effect of Mild Delayed Hypothermia on the Middle Cerebral Artery Occlusion in Spontaneously Hypertensive rats" @default.
- W2382291235 hasPublicationYear "2013" @default.
- W2382291235 type Work @default.
- W2382291235 sameAs 2382291235 @default.
- W2382291235 citedByCount "0" @default.
- W2382291235 crossrefType "journal-article" @default.
- W2382291235 hasAuthorship W2382291235A5076459752 @default.
- W2382291235 hasConcept C126322002 @default.
- W2382291235 hasConcept C142724271 @default.
- W2382291235 hasConcept C204232928 @default.
- W2382291235 hasConcept C25498285 @default.
- W2382291235 hasConcept C2777390192 @default.
- W2382291235 hasConcept C2779740913 @default.
- W2382291235 hasConcept C2780886150 @default.
- W2382291235 hasConcept C2781100881 @default.
- W2382291235 hasConcept C3019162651 @default.
- W2382291235 hasConcept C42219234 @default.
- W2382291235 hasConcept C71924100 @default.
- W2382291235 hasConcept C74864618 @default.
- W2382291235 hasConceptScore W2382291235C126322002 @default.
- W2382291235 hasConceptScore W2382291235C142724271 @default.
- W2382291235 hasConceptScore W2382291235C204232928 @default.
- W2382291235 hasConceptScore W2382291235C25498285 @default.
- W2382291235 hasConceptScore W2382291235C2777390192 @default.
- W2382291235 hasConceptScore W2382291235C2779740913 @default.
- W2382291235 hasConceptScore W2382291235C2780886150 @default.
- W2382291235 hasConceptScore W2382291235C2781100881 @default.
- W2382291235 hasConceptScore W2382291235C3019162651 @default.
- W2382291235 hasConceptScore W2382291235C42219234 @default.
- W2382291235 hasConceptScore W2382291235C71924100 @default.
- W2382291235 hasConceptScore W2382291235C74864618 @default.
- W2382291235 hasLocation W23822912351 @default.
- W2382291235 hasOpenAccess W2382291235 @default.
- W2382291235 hasPrimaryLocation W23822912351 @default.
- W2382291235 hasRelatedWork W101800404 @default.
- W2382291235 hasRelatedWork W1754988322 @default.
- W2382291235 hasRelatedWork W2051632038 @default.
- W2382291235 hasRelatedWork W2099448554 @default.
- W2382291235 hasRelatedWork W2342456556 @default.
- W2382291235 hasRelatedWork W2367062509 @default.
- W2382291235 hasRelatedWork W2378815985 @default.
- W2382291235 hasRelatedWork W2408596901 @default.
- W2382291235 hasRelatedWork W2419482521 @default.
- W2382291235 hasRelatedWork W2711421519 @default.
- W2382291235 hasRelatedWork W2903464707 @default.
- W2382291235 hasRelatedWork W3028907728 @default.
- W2382291235 hasRelatedWork W3029555296 @default.
- W2382291235 hasRelatedWork W3029943509 @default.
- W2382291235 hasRelatedWork W3030691833 @default.
- W2382291235 hasRelatedWork W3031671132 @default.
- W2382291235 hasRelatedWork W3032692263 @default.
- W2382291235 hasRelatedWork W3150026195 @default.
- W2382291235 hasRelatedWork W2160552389 @default.
- W2382291235 hasRelatedWork W2186196449 @default.
- W2382291235 isParatext "false" @default.
- W2382291235 isRetracted "false" @default.
- W2382291235 magId "2382291235" @default.
- W2382291235 workType "article" @default.