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- W2382299237 abstract "AIM:To predict the secondary structure,the B cell epitopes and the HLA-A,B restricted T cell epitopes of human cervical cancer oncogene(HCCR) protein.METHODS:The secondary structure was predicted by the methods of Proteus and SOPMA.The hydrophilicity,surface probability,flexibility and antigenic index were predicted by the methods of Kyte-Doolittle,Emini,Karplus-Schultz and Jameson-wolf,respectively.According to the above methods,the B cell epitopes for HCCR protein were predicted.HLA-A0201-restricted T cell epitopes were predicted by BIMAS,SYFPEITHI and NetCTL.And the restricted T cell epitopes of HLA-B and the other alleles of HLA-A were predicted by NetCTL.RESULTS:The secondary structure of HCCR1 protein was mainly composed of α-helix.The B cell epitopes were probably located at or adjacent to the N-terminal No.41-53,216-228,310-325 and 355-360 regions.And the five predominant HLA-A0201-restricted T cell epitopes were YLVFLLMYL(152-160),YLFPRQLLI(159-167),LLLHNVVLL(343-351),CLFLGIISI(138-146) and SIPPFANYL(145-153).The HLA-A,B restricted T cell epitopes of HCCR protein were probably located at extracelluar domain of protein.CONCLUSION:Prediction of the epitopes of HCCR protein can provide a basis for production of the monoclonal antibody and development of some promising antigen peptides for tumor vaccines." @default.
- W2382299237 created "2016-06-24" @default.
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- W2382299237 date "2007-01-01" @default.
- W2382299237 modified "2023-09-22" @default.
- W2382299237 title "Prediction of B cell epitopes and HLA restricted CTL epitopes of human cervical cancer oncogene protein" @default.
- W2382299237 hasPublicationYear "2007" @default.
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