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- W2382300195 abstract "Objective To investigate the effects of compound ion salt on functional and pathological changes in kidney in spontaneously hypertensive rats (SHR). MethodsSHR (male, n=38) were assigned randomly to receive 8% high salt (HS group); 1% compound ion salt (CIS group); 1% compound ion salt plus 2.25% L-Arg (CIS+L-Arg group); and 1% salt (NS group) for 12 weeks. SBP, body weight, urine volume, urinary sodium excretion and urinary protein excretion were measured every three weeks. The content of Ang Ⅱ and NO in renal cortex were measured by radioimmunoassay (RIA). Renal fibrosis and related pathological changes were quantitatively evaluated.Results Compared with normal-salt diet, 1% compound ion salt or 1% compound ion salt plus 2.25% L-Arg intake delayed and attenuated the increases of the blood pressure in SHR (P0.01), abolished the urinary protein excretion (P0.01). In these two groups, glomerular and tubular interstitial collagen fraction were markedly decreased indicating improvement of kidney injury. The content of Ang Ⅱ in cortex of kidney in these 2 group were decreased and NO was increased, as compared with HS group in which the glomerular and tubular interstitial collagen fraction was increased and kidney injury was significantly manifested. ConclusionCompound ion salt intake delayed and attenuated the progression of high blood pressure and the progression of kidney injury. Supplement with L-Arg appears to have synergetic effect with ion salt." @default.
- W2382300195 created "2016-06-24" @default.
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- W2382300195 date "2006-01-01" @default.
- W2382300195 modified "2023-09-24" @default.
- W2382300195 title "Effects of Compound Ion Salt on Functional and Pathological Changes of Kidney in Spontaneously Hypertensive Rats" @default.
- W2382300195 hasPublicationYear "2006" @default.
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