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- W2382302046 abstract "Objective To construct the plastic-engineered bone prefabricated with alginate gel, osteoblast and bone granules or alginate and bone granules and investigate its effect in repairing the rabbit cranial defects. Methods A total of 24 Japanese white rabbits were randomly divided into Group A and Group B. Bilateral cranial defects for 1 cm in diameter were created and the left defects considered as Group A1 (n=16) and the right defects as Group A2 (n=8). Group A1 were filled with alginate gel-osteoblast-bone granules and Group A2 with alginate gel-bone granules. Group B was used as blank control. Bone regeneration in vivo was observed by means of gross analysis, morphology, image analysis, X ray and measurement of content of calcium and phosphate. Results No abnormal reactions such as red swelling or effusion were seen after implantation of the materials. Twelve weeks after operation in Group A1, many bone-like masses appeared in the newly formed tissues and the tissues surrounding the bone granules partially changed into bone-like tissues, with bone regeneration percentage for (40.92± 19.36 )%, which was significantly higher than that in Group A2 (P 0.05) and Group B (P 0.01). X-ray showed that the skull defects were almost entirely repaired by hard tissues. The amount of Calcium and Phosphorus of tissues repairing the defects was (7.30±0.93) mg and (3.11±0.42) mg respectively in Group A1, which were significantly higher compared with both Group A2, in which the amount of Calcium and Phosphorus was (5.29±0.17) mg and (2.34±0.35) mg and Group B that has the amount of Calcium and Phosphorus for (3.54±0.45) mg and (1.78±0.53) mg respectively. In Group B,the skull defects were mainly repaired by membrane-like soft tissues with only fewbone in marginal area.Radiogram showed that the area of skull defects of Group A1 were full of high-density shade with obviouscontrast that high dense shade only occurred in the marginal area of skull defects of group B. Conclu-sion Engineered bone constructed with alginate gel-osteoblast-bone granule may shape according to thebone defects and can basically repair cranial defects of the rabbits for it has the nice ability toin vivoformbone tissue." @default.
- W2382302046 created "2016-06-24" @default.
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- W2382302046 date "2005-01-01" @default.
- W2382302046 modified "2023-09-23" @default.
- W2382302046 title "Experimental study of bone regeneration of plastic-engineered bone in vivo" @default.
- W2382302046 hasPublicationYear "2005" @default.
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