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- W2382302635 abstract "Objective To investigate the protective role of Jidesheng Sheyao tablet in lipopolysaccharide (LPS)-induced acute lung injury(ALI) in rats. Methods Fifty male SD rats were randomly divided into 6 groups:normal control group,dexamethasone positive group,LPS model group, Sheyao groups of low, middle and high dosages successively.All rats, except normal control group, were administrated with LPS by intravenous injection to induce acute lung injury. The rats in positive group and three different dosage groups were treated by dexamethasone(3 mg·kg -1, iv), low dosage(0.8 g·kg -1), middle dosage(1.6 g·kg -1) and high dosage(3.2 g·kg -1) of Jidesheng Sheyao tablet(oral) respectively before LPS-induced ALI. Each rat in normal control group received injection of 1ml normal saline. The animals were killed after injection of LPS for 2 hours, and then the lung index was calculated, the histopathology of the lung injury was observed by light microscope, the expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) proteins in the lung tissues and their activity in the bronchoalveolar lavage fluid (BALF) and the lung homogenates were detected by immunohistochemistry and zymography separately. Results Compared with model group, the lung indexes were significantly decreased in the drug groups(P0.05); the positive groups were also decreased and was higher than the high dosage group (P0.01). The degrees of lung injury including lung swelling, neutrophil cells infiltration and hemorrhage in the drug groups showed lighter in dose-dependent manner than that of model group. The expression of MMP-2 and MMP-9 in lung tissues was obviously inhibited in the high dosage group and their activity in lung homogenate and BALF also presented dose-dependent inhibition (P0.01)except the activity of MMP-2 in the lung tissue.Conclusion Jidesheng Sheyao tablet has protective effects on endotoxin-induced acute lung injury in rats, and the drug may take effect by means of inhibiting the expression and activity of matrix metalloproteinases in lung tissues and BALF." @default.
- W2382302635 created "2016-06-24" @default.
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- W2382302635 date "2006-01-01" @default.
- W2382302635 modified "2023-09-23" @default.
- W2382302635 title "Protective effects of Jidesheng Sheyao tablet on endotoxin-induced acute lung injury in rats" @default.
- W2382302635 hasPublicationYear "2006" @default.
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