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- W2382304449 abstract "Objective To investigate the inhibition effect on H22 hepatoma by polysaccharides from Tremella fuciformis and explore the mechanism by applying gene expression array chip. Methods The H22 hepatoma model was set up in mice.The inhibition rate was used to evaluate anti-tumor effects of polysaccharide from Tremella fuciformis and tumor inhibitory mechanism was explored by using cDNA microarray. Results The best inhibition rate was showed as 72.3%(P0.01) by Tremella fuciformis polysaccharides at the dose of 6 mg·kg-1.There was expression difference in 324 of the total 4 000 genes compared with negative control groups,185 genes of which were up-regulated and 139 genes were down regulated.By the prelinminary analysis,most of genes were those about signal conduction,DNA injury check/P53 and ATM path,antigen presentation and chemotherapy response. Conclusion The polysaccharide from Tremella fuciformis inhibits H22 hepatoma in mice markedly.The mechanism of action is multitargeted and multiple factors involved,which linking either to cancer associated gene or to immune regulation and signal conduction." @default.
- W2382304449 created "2016-06-24" @default.
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- W2382304449 date "2011-01-01" @default.
- W2382304449 modified "2023-09-28" @default.
- W2382304449 title "Tumor-Inhibitory Effect and Mechanism of Polysaccharide from Tremella fuciformi in Mice" @default.
- W2382304449 hasPublicationYear "2011" @default.
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