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- W2382304874 abstract "Objective To explore the application mechanism of No 1886, a synthetic compound, adjusting glucose and lipid metabolism and the effect on the structure and function of the islets in diabetic Guizhou minipigs induced by high fat and high sucrose feeding. Methods Fifteen Guizhou minipigs about 3-4 months were randomly divided into 3 groups: similar body weight of Normal control diet(CD), high fat high sucrose fed diet(HFSD), and high fat high sucrose fed diet followed by No 1886 treatment (HFSD+No 1886). The fasting concentrations of plasma glucose, triglyceride and serum insulin were analyzed at month 0, 2, 3, 4, 5, 6, and 8 respectively. The animals were sacrificed at the end of month 8 Samples of pancreas were cut and fixed in 10% formalin, paraffin embedded, sectioned and stained with HE. Other sections were stained with an antibody to porcine insulin. After immunostaining, sections were photographed and the percent areas occupied by β cells were measured in all of the three groups by plamimetry with the software IMAGE J. A part of pancreas was fixed with 4℃, 2 5% glutaraldhyde, sampled by means of normal electronic microscope, and observed and photographed under transmit electronic microscope. Results High fat high sucrose feeding elevated fasting plasma glucose, triglyceride and serum insulin levels significantly. These values were significantly higher than those in Normal control group ( P 0 05). Supplement of No 1886 into high fat high sucrose diet induced a decrease in plasma glucose, triglyceride and insulin concentration compared with pigs fed with the sole high fat high sucrose diet. The observation of pancreatic islets micro structure and ultra structure and immunostaining results of islet β cells showed that the high fat and high sucrose feeding damaged the pancreatic tissues structure and the structure and function of the β cells. But No 1886 had a protection of pancreatic tissues structure,and the structure and function of β cells. Conclusion No 1886 suppressed plasma glucose and triglyceride level, and alleviated insulin sensitivity and β cell damage as well." @default.
- W2382304874 created "2016-06-24" @default.
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- W2382304874 date "2004-01-01" @default.
- W2382304874 modified "2023-09-23" @default.
- W2382304874 title "Protection of Guizhou Miniature Pigs Islet Cells by the Lipoprotein Lipase Activator No-1886 against Glucotoxicity and Lipotoxicity" @default.
- W2382304874 hasPublicationYear "2004" @default.
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