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- W2382325853 abstract "Objective:To investigate the value of the detection of Ph chromosome and bcr/abl fusion gene in the diagnosis?treatment and prognosis in chronic myelogenous leukemia (CML).Methods:Forty one patients were studied,and those with Ph chromosome positive and bcr/abl fusion gene positive chronic phase chronic myeloid leukemia were divided into two groups at random.One group were treated with Hu and bestatin and the another were treated with Hu and IFN α.Marrow samples from them were analyzed by G banding technique and RT nest PCR method six months later.Rusults:1)Ph chromosome and bcr/abl fusion gene were both positive in 36 and Ph bcr/abl +in 5.b 3a 2 type was detected in 29 and b 3a 2 type was deteted in 12.2)In IFN α group,all got CHR.Among them,two got partial cytogenetic remission (PCR) and four got minor cytogenetic remission(MiCR).All cases got CHR in bestatin group,in which 6 got MiCR.3)None got molecular biology response in both groups.4)Cytogenetic response can be detected in both groups and there is no difference between the two groups.Conclusion:1)Both Ph chromosome and bcr/abl fusion gene were important figures in diagnosis of CML and combining both is more evaluable. 2)The change of Ph chromosome reflect the effect of treatment and its prognosis. 3)Both groups can get cytogenetic response( P 0.01).There is no apparent statistical difference detween the two groups( P 0.05)." @default.
- W2382325853 created "2016-06-24" @default.
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- W2382325853 date "2001-01-01" @default.
- W2382325853 modified "2023-10-08" @default.
- W2382325853 title "CLINICAL SIGNIFICANCE OF Ph CHROMOSOME AND bcr/abl FUSION GENE IN CHRONIC MYELOGENOUS LEUKEMIA" @default.
- W2382325853 hasPublicationYear "2001" @default.
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